—-An kwafi wannan labarin dagaMedpage Yau
Cire duka ovaries kafin lokacin haila yana da alaƙa da mafi girman yiwuwar matsalolin kiwon lafiya na yau da kullun da rage yawan aiki na jiki bayan shekaru, musamman a cikin matan da aka yi wa tiyata a baya, binciken da aka gano.
Idan aka kwatanta da ƙungiyar da ta dace da shekaru, matan da ke ƙasa da 46 waɗanda aka yi wa premenopausal oophorectomy (PBO) don yanayi mara kyau - tare da ko ba tare da hysterectomy ba - sun yi ƙasa da kyau akan gwajin tafiya na mintuna shida da aka gudanar a wani asibiti na waje shekaru ashirin bayan haka kuma sun fi dacewa. don samun yanayi na yau da kullun:
Asthma: ko 1.74 (95% CI 1.03-2.93)
Arthritis: ko 1.64 (95% CI 1.06-2.55)
Rashin barci mai hanawa: ko 2.00 (95% CI 1.23-3.26)
Karya: ko 2.86 (95% CI 1.17-6.98)
"Wadannan sakamakon suna nuna tasirin mummunan tasirin oophorectomy na dogon lokaci ga matan da ba su da kyau ko kuma babu alamun ovarian waɗanda ke da matsakaicin haɗarin kwayoyin cutar kansa," in ji masu binciken Michelle Mielke, MD, PhD, na Makarantar Jami'ar Wake Forest. Magunguna a Winston-Salem, NC, a cikin labarin a Menopause.Wadannan sakamakon suna da mahimmanci yayin la'akari da ko za a sha ovariectomy (PBO) da hysterectomy.
Stephanie Faubion, MD, MBA, darektan likita na Menopause Society, ya ce binciken, wanda ya dogara da Mayo Clinic's Tubectomy and Aging Cohort Study-2 (MOA-2), ya tabbatar da bukatar likitocin su canza ayyukansu.
"Wannan kawai yana ƙarawa ga wallafe-wallafen da ke da cewa cire ovaries a lokacin ƙanana, musamman ma a ƙarƙashin shekaru 46, yana da alaƙa da rashin lafiya sakamakon," Faubion ya gaya wa MedPage A Yau."A wannan lokacin, ina ganin kawai muna bukatar daukar mataki."
Faubion, wacce kuma ita ce darektan Cibiyar Kula da Lafiyar Mata a Mayo Clinic da ke Rochester, Minnesota, amma ba ta shiga cikin binciken na yanzu ba, ta ce yin aure daga baya (mata masu shekaru 46 zuwa 49) kuma “ba a yi aure ba. kyakkyawan tunani,” a cewar binciken.A cikin wannan rukuni, an sami ƙarin rashin daidaituwa na arthritis da barci na barci idan aka kwatanta da takwarorinsu masu dacewa da shekaru, kuma PBO ya haifar da rashin daidaituwa na cututtukan cututtuka na huhu a cikin dukan ƙungiyar.
A cikin rukunin PBO, kusan kashi 90 cikin 100 kuma an yi musu tiyatar hysterectomy, kuma kashi 6 cikin 100 na da mahaifa kafin wannan;a cikin ƙungiyar da ta dace da shekarun da ba ta sha PBO ba, kashi 9 cikin 100 na da mahaifa.
Mielke ya gaya wa MedPage A Yau cewa cire ovaries a lokacin hysterectomy (na biyu mafi yawan tiyata ga mata) al'ada ce ta kowa ga mata, a wani ɓangare saboda yana kawar da hadarin ciwon daji na ovarian.
“A tarihi,” in ji Mielke, “an yi imani cewa da zarar an cire mahaifar, ba za a sake samun ikon haifuwa ba, saboda haka ba za a bukaci a cire kwai ba.”Duk da haka, bayan lokaci, ƙarin bincike ya nuna cewa cire ovaries biyu kafin lokacin haila na iya haifar da sakamako na dogon lokaci ko haɗarin wasu cututtuka na dogon lokaci.
Idan an cire ovaries kafin al'ada na al'ada, Milk ya ce, "an ba da shawarar sosai" cewa mata su ci gaba da yin maganin estrogen har zuwa shekaru 50.
Masu binciken sun lura cewa binciken na yanzu ya haɗa da cikakkiyar kima na jiki na mata tare da tarihin PBO da aka rubuta, yayin da sauran nazarin kan PBO da sakamakon kiwon lafiya sun dogara da farko a kan tarin sakamakon da aka samu daga bayanan likita, da kasa kama "yanayi na musamman. na aikin jiki ko wasu matakan da suka shafi tsufa."
Cikakken bayani
Mielke da abokan aiki sun yi amfani da bayanai daga Rochester Epidemiology Project's (REP) Medical Record Linkage System da kuma binciken MOA-2, wanda ya gano mata a cikin Olmsted County, Minnesota, waɗanda aka yi musu magani tare da PBO don yanayi mara kyau tsakanin 1988 da 2007 kuma waɗanda ba su kasance a wurin ba. Babban haɗari ga ciwon daji na ovarian. An kwatanta mahalarta MOA-2 tare da ƙungiyar mata waɗanda ba su karbi PBO ba tare da ƙungiyar mata waɗanda ba su karbi PBO ba.
Tun daga 2018, lokacin da aka fara nazarin fuska da fuska, yawancin waɗanda ke cikin PBO da ƙungiyoyin tunani har yanzu suna raye (91.6% da 93.1%, bi da bi).
Ƙungiyar binciken ta ɗauki mata 274 masu magana da Ingilishi daga MOA-2 waɗanda suka bibiyi ta cikin mutum tare da PBO bayan tsaka-tsakin shekaru 22, ciki har da marasa lafiya 161 waɗanda suka fara aikin da wuri (kafin shekaru 46) (59%) da marasa lafiya 113. wanda ya yi aikin a ƙarshen (shekaru 46 zuwa 49) (41%).
Dole ne mahalarta su kasance shekaru 55 ko fiye a lokacin yin rajista kuma an cire su idan ilimin cututtuka ya nuna rashin lafiya a cikin PBO ko kuma idan ba a gan su a cikin REP ba a cikin shekaru 5 da suka wuce.Sun kasance shekaru-daidai da mahalarta 240 a cikin ƙungiyar tunani waɗanda ba su da PBO.
Gabaɗaya, matan suna da matsakaicin shekaru 67, sun kasance 97% -99% farare, kuma kusan 60% basu taɓa shan taba ba.
An tantance cututtuka na yau da kullun ta bayanan likita.Baya ga ƙungiyoyin da aka ambata a baya, masu binciken ba su sami ƙungiyoyi tsakanin PBO da ciwon daji ba, ciwon sukari, lalata, hauhawar jini, hyperlipidemia, cardiac arrhythmia, koda, thyroid, ko cutar hanta, osteoporosis, ko harin ischemic na wucin gadi.
Gwajin jiki ya haɗa da matakan ƙarfi da motsi.Idan aka kwatanta da ƙungiyar da ta dace da shekaru, matan da suka shiga PBO suna da ƙwayar thyroid / pteronavicular mafi girma kuma sun yi rashin kyau a kan gwajin tafiya na minti 6 (mita 14), yayin da matan da suka fara PBO sun fi kyau a kan minti 6. gwajin tafiya (-18 mita).Mata a cikin ƙarshen ƙungiyar PBO suna da matsakaicin matsakaicin matsakaicin adadin kitsen mai, ƙwayar appendicular, da ƙarancin ma'adinai na kashin baya idan aka kwatanta da ƙungiyar tunani.
Mielke da abokan aiki sun lura cewa saboda binciken ya kasance mai ban sha'awa, ba za a iya yin la'akari da dalilin ba, kuma ana ba da shawarar yin nazari na dogon lokaci.Har ila yau, sun lura cewa matan da suka shiga binciken na iya samun lafiya fiye da sauran jama'a tare da nuna fifikon fararen fata a matsayin daya daga cikin iyakokin binciken.
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Lokacin aikawa: Satumba 18-2023